The mean arterial pressure MAPalso considered as the perfusion pressure, is taken as the pressure difference between the arteries and the veins. The regulation of blood pressure is done in order to maintain the MAP. The MAP dictates the amount of oxygen and nutrients that is supplied by the blood vessels and the waste that is carried away from the tissues. The body has the ability to counteract long term as well as short term changes in blood pressure.
The long term pressure changes cause the body to respond through the activation of renin-angiotensin system. The baroreceptors are the pressure sensing bodies.
They are also called stretch receptors. They are modified nerve endings attached to the cytoskeleton present within the nerve endings. The baroreceptors and blood pressure are densely situated on the walls of the arch of aorta and the carotid sinus.
The carotid sinus is present on the base of internal carotid artery at the level of bifurcation of the common carotid artery. The sinus area is slightly dilated as the tunica media which is normally comprised of muscles, is relatively thin. The tunica adventitia, on the other hand, is thicker than usual. This is the layer of the blood vessels where the nerve receptors are situated. Same is true for the location of baroreceptors on the arch of aorta. Rapid offsets in pressure can occur, for example, in a previously standing person who suddenly sits down, baroreceptors and blood pressure.
During the process, a large volume of blood is shifted from the peripheral to the central regions of the body. Consequently, a large volume of blood enters the heart and this volume overload or increased preload causes the heart to increase its cardiac output. A simultaneous increase in blood pressure will also be observed with increase in cardiac output.
The increase in blood pressure is registered by the baroreceptors. Similarly, a drop in blood pressure is registered by the baroreceptors when the person stands up suddenly from a sitting position. High blood pressure in the blood vessels causes stretch of these receptors which results in movement of sodium ions into the nerve endings, thereby, initiating an action potential.
These baroreceptors have a baroreceptors and blood pressure firing pattern. That baroreceptors and blood pressure they have an intrinsic potential to generate action potentials at a particular frequency at all times. This frequency is increased when the baroreceptors receive a stretch stimulus secondary to increase in blood pressure. The carotid sinuses increase their rate of impulse generation when the pressure in them builds up to values greater than 50 mm Hg.
Below this threshold pressure, the carotid baroreceptors fail to initiate an action potential. On the other hand, baroreceptors and blood pressure, the arch of aorta can record drops baroreceptors and blood pressure blood pressure up to 30 mm Hg, baroreceptors and blood pressure. The upper limit for blood pressure, after which the frequency of action potential stops increasing, is mm Hg. The normal MAP is calculated to be 93 mm Hg. At this pressure, the baroreceptors are believed to be the most sensitive and even slight changes in pressure will result bactrim and sun exposure rapid firing of action potentials.
At blood pressures lower than 30 mm Hg, the chemoreceptors come into play. The chemoreceptors function by sensing the arterial concentration of carbon dioxide, oxygen, Ph and other metabolites. They do not detect changes in blood baroreceptors and blood pressure. Afferent impulses from the carotid sinus are carried by the Herring nerve, a branch of Glossopharyngeal nerve CN In the case of baroreceptors present on the arch of aorta, baroreceptors and blood pressure, the Vagus nerve CN is the afferent nerve that carries impulses to the spinal cord.
Both, the Vagus nerve and the Glossopharyngeal nerve, feed impulses from the baroreceptors into the nucleus of tractus solitarius. These nuclei are situated in the medulla of the spinal cord and their job is to process the incoming afferent impulses.
These centers receive processed impulses from the nucleus of tractus solitarius and from here efferent impulses in the form of sympathetic and parasympathetic nerves arise. Impulses are carried to the heart via the parasympathetic Vagus nerve. Sympathetic impulses travel down the intermedio-lateral segment of the spinal cord and give rise to efferent motor spinal nerves which enter the sympathetic ganglion running parallel to the spinal cord.
Postganglionic sympathetic nerves ultimately supply the heart and the peripheral vasculature. Another preganglionic sympathetic nerve also supplies the adrenal medulla which results in the release of epinephrine and norepinephrine, which further contribute in enhancing the sympathetic activity. The end result is either an increase or decrease in the blood pressure, thereby correcting the disturbance in hemodynamics of the body. This phenomenon is also referred to as the buffering effect, since the change in pressure is buffered back to normal, baroreceptors and blood pressure.
The Vagus and Glossopharyngeal nerves, because of the same reason, are therefore known as the buffering nerves. The stroke volume baroreceptors and blood pressure altered by altering the force of contractility of the heart muscles.
The sympathetic nerves supplying the heart muscles affect the stroke volume. The parasympathetic nerves supplying the SA and AV node are responsible for producing changes in heart rate. The TPR can be increased or decreased by changing the diameter of peripheral vasculature which is under the control of the sympathetic nervous system. Massaging the carotid sinuses physically increases the pressure on the baroreceptors present there. The carotid baroreceptors respond by increasing the rate of afferent impulse firing.
The sympathetic system will be shut down and the parasympathetic system is activated. This results in decrease in blood pressure of the body. Carotid massage by activating parasympathetic nervous system increases AV nodal refractory period, baroreceptors and blood pressure, thereby decreasing AV node conduction and finally decreasing Heart Rate.
This is the reason Carotid sinus massage is the initial menuever used in the treatment of paroxysmal supra-ventricular tachycardia. Stenosis of carotids proximal to the sinus or obstruction of the carotids due to atherosclerosis will cause the baroreceptors to register a decrease in pressure. Therefore, sympathetic system activation follows. Increased sympathetic activity causes a resultant increase in blood pressure, baroreceptors and blood pressure. This increase in blood pressure may cause hypertension in an otherwise normal person.
The baroreceptors also have the ability to adapt to chronic changes in blood pressure. If the mean pressure is changed over time to a new value, the baroreceptors will start using that MAP as the baseline. Any subsequent blood pressure changes will then be rectified keeping in view the new baseline value of MAP.
View all posts by Drbeen. You are commenting using your WordPress. You are commenting using your Twitter account. You are commenting using your Facebook account. Notify me of new comments via email. Mean Arterial Pressure The mean arterial pressure MAPalso considered as the perfusion pressure, is taken as the pressure difference between the arteries and the veins.
Regulation Of Blood Pressure The body has the ability to counteract long term as well as short term changes in blood pressure, baroreceptors and blood pressure. Baroreceptors are present on the arch of aorta and carotid sinus Chemoreceptors are present in the carotid sinuses, arch of aorta and medulla oblongata Atrial receptors are present on the wall of right atrium Baroreceptors The baroreceptors are the pressure sensing bodies.
Baroreceptor Reflex The baroreceptor reflex like other reflex arcs is comprised of three units: Afferent nerve carrying impulses from the receptors Central processing unit An efferent nerve that innervates the effector Afferent impulses from the carotid sinus are carried by the Herring nerve, a branch of Glossopharyngeal nerve CN Reduction in blood pressure will result in a decrease in the number of afferent impulses from the baroreceptors.
The sympathetic activity will increase and as a result, the TPR, HR and the stroke volume will all increase. At the same time, the parasympathetic input will taper down. All these changes will result in increasing the blood pressure back to normal. This happens in situations like exercise or stress. Increased blood pressure will result in stretching of the stretch receptors. This increases the frequency of afferent impulses.
Sympathetic supply will decrease and the parasympathetic system will take over. Finally, the blood baroreceptors and blood pressure is decreased back to normal. Occurs in situations of vomiting, diarrhea, hemorrhage etc. As a result of these, both the volume, and therefore pressure of the blood decreases. Afferent impulse firing of the baroreceptors decreases. Due to an increase in these parameters, the blood pressure is raised back to normal.
This increased afferent input from the baroreceptors results in activation of the PANS. Once activated, the parasympathetic nervous system decreases the blood pressure back to normal.
Massaging The Carotid Sinus Massaging the carotid sinuses physically increases the pressure on the baroreceptors present baroreceptors and blood pressure. Stenosis Of The Carotids Stenosis of carotids proximal to the sinus or obstruction of the carotids due to atherosclerosis will cause the baroreceptors to register a decrease in pressure.
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