Avoid; strong anticholinergic and sedative effects; may cause clomipramine and nifedipine hypotension Beers criteria. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial months of therapy and dosage adjustments.
Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy. Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy.
Clinical worsening and suicide ideation clomipramine and nifedipine occur despite clomipramine and nifedipine in adolescents and young adults yr. Potentially life-threatening serotonin syndrome reported when coadministered with drugs that impair serotonin metabolism in particular, MAOIs, including nonpsychiatric MAOIs, such as linezolid and IV methylene blue. Rare cases of drug rash with eosinophilia and systemic symptoms DRESS reported with use; in event of severe acute reactions such as DRESS, discontinue clomipramine therapy immediately and institute appropriate treatment.
Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal clomipramine and nifedipine showed minor risks and human studies done and showed no risk. Use with caution if benefits outweigh risks, clomipramine and nifedipine. Animal studies show risk and human studies not available or neither animal nor human studies done.
Positive evidence of human fetal risk. Do not use in pregnancy. Risks involved outweigh potential benefits. Steady-state therpaeutic plasma concentration: Adding plans allows you to compare formulary status to other drugs in the same class. To view formulary information first create a list of plans. Your list will be saved and can be edited at any time. The above information is provided for general clomipramine and nifedipine and educational purposes atlas area and blood pressure. Individual plans may vary and formulary information changes.
Contact the applicable plan provider for the most current information. By clicking send, clomipramine and nifedipine, you acknowledge that clomipramine and nifedipine have permission to email the recipient with this information, clomipramine and nifedipine.
If you log out, you will be required to enter your username and password the next time you visit. Brand and Other Names: Share Email Print Feedback Close, clomipramine and nifedipine. Significant - Monitor Closely. All Interactions Sort By: Rare Myocardial infarction, orthostatic hypotension Depression worsening, suicidal thoughts suicide, seizure Hyperglycemia Agranulocytosis, leukopenia, pancytopenia, thrombocytopenia Body temperature above normal Drug rash with eosinophilia and systemic symptoms DRESS.
Contraindications Hypersensitivity Severe cardiovascular disorder Narrow angle glaucoma Any drugs or conditions that prolong QT interval Acute recovery post-MI Coadministration with serotonergic drugs Concomitant with or within 14 d of MAOIs serotonin syndrome Starting clomipramine in a patient who is being treated with linezolid or IV methylene blue is contraindicated because of an increased risk of serotonin syndrome If linezolid or IV methylene blue must be administered, discontinue clomipramine b natriuretic peptide and pioglitazone and monitor for CNS toxicity; may resume clomipramine 24 hr after last linezolid or methylene blue dose or after 2 weeks of monitoring, whichever comes first.
Pharmacology Mechanism of Action Parent drug may affect serotonin uptake; active metabolite may may affect norepinephrine uptake. Pharmacokinetics Peak Plasma Time: Print without Office Info.
Print with Office Info. Formulary Formulary Patient Discounts. Create Your List of Plans. View explanations for tiers and restrictions. Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. Most commonly, these are "preferred" on formulary brand drugs, clomipramine and nifedipine.
Most commonly, these are "non-preferred" brand drugs. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription. OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Non-Medicare Plans Medicare Plans. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. What would you like to print? Print this section Print the entire contents of. This website also contains material copyrighted by 3rd parties.
Most Popular Articles According to Psychiatrists. Need clomipramine and nifedipine Curbside Consult? Share cases and questions with Physicians on Medscape consult. This drug is available at a middle level co-pay. This drug is anxiety and vitamin defiency at a higher level co-pay. Prior Authorization Drugs that require prior authorization. Quantity Limits Drugs that have quantity limits associated with each prescription.
Step Therapy Drugs that have step therapy associated with each prescription. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.